বহুল ব্যবহত Antifungal Itraconazole ** Oral,IV,Syrup সব ভাবেই পাওয়া যায়..
Absorption বাড়ে ভরা পেটে খেলে
Molds and Endemic dimorphic fungi এর বিরুদ্ধে ভালো কাযকারিতা রয়েছে,,যা Fluconazole এর নেই…
ড্রাগ অফ চয়েজ -Histoplasmosis and Blastomycosis এ ,এছাড়াও Chronic Coccidioidomycosis, phaeohyphomycosis, sporotrichosis, ক্যান্ডিডিয়াসিস, টিনিয়া ভার্সিকলার, টিনিয়া ক্যাপিটিস এবং অনাইকোমাইকোসিস।
Tablet 1:-Itra 200mg (As A Itraconazole AS A Drugs for subcutaneous and mycoses).
Capsule 2:Itra 100mg (As A Itraconazole AS A Drugs for subcutaneous and mycoses).
Oral solution 3: Itra 50mg/5ml (As A Itraconazole AS A Drugs for subcutaneous and mycoses).
Indications of Tablet :-Itra 200mg (As A Itraconazole AS A Drugs for subcutaneous and mycoses).
Itra is used for the treatment of oropharyngeal candidiasis, vulvovaginal candidiasis, pityriasis versicolor, tinea pedis, tinea cruris, tinea corporis, tinea manuum, onychomycosis, histoplasmosis. It is indicated in the treatment of systemic candidiasis, aspergillosis, and cryptococcosis (including cryptococcal meningitis). It is also used for maintenance therapy in AIDS patients to prevent relapse of underlying fungal infections and in the prevention of fungal infection during prolonged neutropenia.
Pharmacology of Tablet :-Itra 200mg (As A Itraconazole AS A Drugs for subcutaneous and mycoses).
Itraconazole inhibits Cytochrome P-450 dependent enzymes resulting in impairment of the biosynthesis of ergosterol, a major component of the cell membrane of yeast and fungal cells. Being integral to the proper functioning of the cell membrane, inhibition of the synthesis of ergosterol leads to a cascade of abnormalities in permeability, membrane bound enzyme activity, and co-ordination of chitin synthesis leading to inhibition of growth, abnormal cell wall formation and accumulation of intracellular lipids and membranous vesicles.
SUBA (Super Bio-available) technology is a novel technology for enhancing the bioavailability of poorly soluble drugs. This technology utilizes a solid dispersion of drug in a polymer that improves the dissolution of poorly soluble drugs compared to their normal crystalline form. SUBA technology Itraconazole is an orally active triazole antifungal drug that has demonstrated a broad spectrum of activity and favorable pharmacokinetic profile.
Dosage & Administration of Tablet :-Itra 200mg (As A Itraconazole AS A Drugs for subcutaneous and mycoses).
100 & 200 mg preparation:
For non-systemic fungal disease-
- Vulvovaginal candidiasis: 200 mg twice daily for 01 day
- Pityriasis versicolor: 200 mg once daily for 07 days
- Tinea corporis, tinea cruris: 100 mg once daily for 15 days or 200 mg once daily for 7 days
- Tinea pedis, tinea manuum: 100 mg once daily for 30 days
- Oropharyngeal candidiasis: 100 mg once daily for 15 days, Increase dose to 200 mg once daily for 15 days in AIDS or neutropenic patients because of impaired absorption in these groups.
- Onychomycosis (toenails with or without fingernail involvement): Either 200 mg daily for 3 months or course (pulse) of 200 mg twice daily for 7 days, subsequent courses repeated after 21 days’ interval. Fingernails two courses, toenails three courses.
For systemic fungal disease-
- Aspergillosis: 200 mg once daily for 2-5 months Increase dose to 200 mg twice daily in case of invasive or disseminated disease
- Candidiasis: 100-200 mg once daily for 3 weeks-7 months. Increase dose to 200 mg twice daily in case of invasive or disseminated disease
- Non-meningeal Cryptococcosis: 200 mg once daily for 10 weeks
- Cryptococcal meningitis: 200 mg twice daily for 2-6 months
- Histoplasmosis: 200 mg once daily twice daily for 8 months
- Maintenance in AIDS: 200 mg once daily until immune recovery
- Prophylaxis in neutropenia: 200 mg once daily until immune recovery
The dose and duration of treatment for systemic antifungal disease should be adjusted depending on the clinical response.
65 mg & 130 mg preparation:
For non-systemic fungal disease-
- Vulvovaginal candidiasis: 130 mg twice daily for 1 day
- Pityriasis versicolor: 65 mg twice daily for 7 days
- Tinea corporis and tinea cruris: 65 mg daily for 15 days OR 65 mg twice daily for 7 days
- Tinea pedis and tinea manuum: 65 mg once daily for 30 days
- Oropharyngeal Candidiasis: 65 mg once daily for 15 days, increase dose to 65 mg twice daily for 15 days in AIDS or neutropenic patients because of impaired absorption in these groups.
- Onychomycosis (toenails with or without fingernail involvement): Either 65 mg twice daily for 3 months or course (pulse) of 130 mg twice daily for 7 days, subsequent courses repeated after 21 days interval. Fingernails two courses, toenails three courses.
For systemic fungal disease-
- Aspergillosis: 65 mg twice daily for 2-5 months.Increase dose to 130 mg twice daily in case of invasive or disseminated disease
- Candidiasis: 65-130 mg once daily for 3 weeks-7 months. Increase dose to 65 mg twice daily in case of invasive or disseminated disease
- Non-meningeal Cryptococcosis: 65 mg twice daily for 10 weeks
- Cryptococcal meningitis: 130 mg twice daily for 2-6 months
- Histoplasmosis: 130 mg once daily-twice daily for 8 months
- Maintenance in AIDS: 65 mg twice daily until immune recovery
- Prophylaxis in neutropenia: 65 mg twice daily until immune recovery
The dose and duration of treatment for systemic anti-fungal disease should be adjusted depending on the clinical response.
pediatric use: The efficacy and safety of the Itraconazole capsule have not been established in pediatric patients.
Side Effects of Tablet :-Itra 200mg (As A Itraconazole AS A Drugs for subcutaneous and mycoses).
Nausea, abdominal pain, dyspepsia, constipation, headache, dizziness, raised liver enzymes, menstrual disorders, allergic reactions (including pruritus, rash, urticaria and angioedema), hepatitis and cholestatic jaundice, peripheral neuropathy and Stevens-Johnson syndrome reported. On prolonged use hypokalaemia, oedema and hair loss reported.
ইট্রাকোনাজল একটি potent CYP3A4 inhibitors *ড্রাগ ইন্টারেকশন with Rifamycins…
ইট্রাকোনাজল হেপাটিক & Cardiac Toxicity করতে পারে,,এবং which menifest CCF****
টিনিয়া Versicolor এ সিস্টেমিক এন্টিফাংগাল এর ক্ষেত্রে ড্রাগ অফ চয়েজ Itraconazole ** Terbinafin ইফেক্টিভ নয়,,,
Antifungal লিভার কে Damage করে ,তাই Antifungal দেওয়ার আগে Liver function test করে নিবেন
Raiyyan Tahsan Date:-28-12-2024 Saturday Time:-6-11-35 pm
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