Mupirocin হলো টপিক্যাল এন্টিবায়োটিক এজেন্ট। গ্রাম পজেটিব Cocci এর বিরুদ্ধে কাজ করে( MRSA এর বিরুদ্ধে Sensitive)। সুপারফিশিয়াল স্কিন ইনফেকশন এর Against বেশ কার্যকর!(Impetigo,Boils,Folliculitis,2ndry স্কিন ইনফেকশন_এছাড়াও যেগুলো মূলত Staphylococcus aureus or strepto. pyogen দিয়ে হয়ে থাকে) কাটাছেড়া তে সেলাই কাটার পর আক্রান্ত স্থানে ব্যবহার করা হয়ে থাকে…..স্কিন & সফট টিস্যু infections are treated best with local wound care by Mupirocin
তবে Mupirocin_ Anarobic ব্যাকটেরিয়া,mycobacteria, mycoplasma, chlamydia, yeast& fungi এর বিরুদ্ধে কার্যকর নয়…
Mupirocin Protien_sysnthesis_inhibit এর মাধ্যমে কাজ করে…
টপিকেলি Intact স্কিন ই Use করা হয় বলে appreciably Systemically Absorbed হয় না। Minimally সিস্টেমিক Absorbed _1% এর ও কম__large ইনফেক্টেট এরিয়া যেমন _decubitus ulcers & open surgical wounds,Clean cut wound এ Recommended নয়
দীর্ঘ সময় ব্যবহার এ %Fungi এর গ্রোথ বেরে যায়।
বাজারে All are same drug under sub classe Mupirocin:-
• Bactrocin
• Trego
• Mupiron
• Bactroderm
• Mupiderm নামে পাওয়া যায়
Ointment 1:-Bactrocin 2%W/W 10Gm Tube( AS A Mupirocin AS A Topical Antibiotic preparations).
Indications of Ointment :-Bactrocin 2%W/W 10Gm Tube( AS A Mupirocin AS A Topical Antibiotic preparations):-
Bactrocin ointment is indicated for the topical treatment of impetigo (skin diseases) due to Staphylococcus aureus and Streptococcus pyogenes. It is also indicated in folliculitis, furunculosis.
Pharmacology of Ointment :-Bactrocin 2%W/W 10Gm Tube( AS A Mupirocin AS A Topical Antibiotic preparations):-
Mupirocin is a naturally occurring antibiotic. It is an antibacterial agent produced by fermentation using the organism Pseudomonas fluorescens. It is active against a wide range of bacteria those responsible for the majority of skin infections, e.g. Staphylococcus aureus including methicillin-resistant Staphylococcus aureus (MRSA) other staphylococci and streptococci. It is also active against certain gram-negative pathogens, like Escherichia coli and Haemophilus influenzae. Mupirocin inhibits bacterial protein synthesis by reversibly and specially binding to bacterial isoleucyl transfer-RNA synthetase. Due to this unique mode of action, Mupirocin demonstrates no in vitro cross-resistance with other classes of antimicrobial agents. Mupirocin is bactericidal at concentrations achieved by topical administration. However, the minimum bactericidal concentration (MBC) against relevant pathogens is generally eight-fold to thirty-fold higher than the minimum inhibitory concentration (MIC).
Mupirocin is a naturally occurring antibiotic. This antibacterial agent is produced by fermentation using the organism Pseudomonas fluorescens. It is active against a wide range of bacteria (e.g. Staphylococcus aureus including methicillin-resistant strains and Streptococcus pyogenes) those responsible for the majority of skin infections. It is also active against gram-negative pathogens, such as Escherichia coli and Haemophilus influenzae. Mupirocin inhibits bacterial protein synthesis by reversibly and specifically binding to bacterial isoleucyl transfer-RNA synthetase.
Dosage & Administration of Ointment :-Bactrocin 2%W/W 10Gm Tube( AS A Mupirocin AS A Topical Antibiotic preparations):-
A small amount of Bactropen ointment should be applied to the affected area 3 times daily for up to 10 days. The safety and effectiveness of Mupirocin ointment have been established in the age range of 2 months to 16 years.
Pediatric Use: The safety and effectiveness of Mupirocin have been established in the age range of 2 months to 16 years. Use of the ointment in these age groups is supported by evidence from adequate and well-controlled studies of Mupirocin in impetigo in pediatric patients.
Side Effects of Ointment :-Bactrocin 2%W/W 10Gm Tube( AS A Mupirocin AS A Topical Antibiotic preparations):-
Reported side effects are burning, stinging or pain, itching and some patient may be suffered rash, nausea, erythema, dry skin, tenderness, swelling, contact dermatitis and increased exudate.
Pregnancy_&_Brestfeeding এ সেইফ
Normal টপিক্যাল Dose_(2 -3 )বার—-১০দিন
Prolong ব্যবহারেও রেজিস্টেন্স গ্রো করতে পারে,,তাই
রেজিস্টেন্স গ্রোথ প্রতিরোধ করার জন্য ১০ দিন এর বেশি ব্যবহার না করাই ভালো
Raiyyan Tahsan Date:-28-12-2024 Saturday Time:-5-42-33 pm
- TC(1487).(56). General Medicine Department Case No (14): Presumed Treated Hypertension and Type 2 Diabetes with Possible Upper-GI Dyspepsia/Dysmotility and Cardiovascular Risk Management (1 Prescription + 0 Reports + 0 Supporting Images).5432
- TC(1486).(02). Dermatology Department Case No 107:- Suspected Superficial Dermatophytosis with Possible Coexisting Allergic Rhinitis: Clinical Diagnosis, Prescription Analysis and Evidence-Based Management (1PR+0RE+0IMG)4433
- TC(1485).(02). Dermatology Department Case No (106): Undifferentiated Genital Ulcer Disease with Associated Skin Rash and Generalized Weakness Suspected Syphilis versus Genital Herpes; Possible Secondary Bacterial Infection (1 PR+ 0RE + 0Img)7799
- TC(1484).(09).Obstetrics & Gynecology Case No 60:-High-Risk Pregnancy with History of Two Preterm Deliveries and Two Neonatal Deaths: Diagnosis, Drug Safety and Evidence-Based Management(1PR+0RE+0IMG)8090
- TC(1483).(09). Gynecology Department Case No. (59): Physician-Documented Mastitis with Fever — Possible Inflammatory or Bacterial Mastitis; Breast Abscess and Dengue Fever to Be Excluded (1Prescription + 0Reports + 0Images)0909