Management Case No 9. Lipid Management

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Management Case No 9. Lipid Management

দুই_মিনিটে_লিপিড_ম্যানেজমেন্ট_শিখে_নিন–

TG বেশি, TC নরমাল, Fenofibrate

TC বেশি, TG normal, Rx হবে statin

TC বেশি, TG নরমালের চেয়ে বেশি But 500 থেকে কম…

Rx হবে statin

TC বেশি + TG ও ৫০০ থেকে বেশি

তখন সকালে Fenofibrate, রাতে statin

Atorvastatin কখন দিবেন?

Rosuvastatine কখন দিবেন?

উত্তর– দুইটাই Lipid lowering agent,

Atova থেকে Rosuva এর efficacy ভালো-

statin এর indication থাকলে যে কোনো একটা দিয়ে শুরু করা যায়– Atorvastatin এর Drug interaction অনেক,

সেই হিসাবে Rosuva Drug interaction কম

Atova 10 mg = Rosuva 5 mg

LDL and Total cholesterol level দুইটাই শরীরের জন্য ক্ষতিকর, এই দুইটা কমানোর সাথে সাথে HDL level বৃদ্ধি করতে পারলে cardiac patient দের উপকার হয়,

এখন আপনি যদি HDL level বাড়াতে চান, তাহলে study তে দেখা গেছে, Rosuvastatin তুলনামূলকভাবে HDL level বাড়ায়- তাই কারো যদি HDL level কম থাকে, তাদের ক্ষেত্রে

Rosuva দেওয়া হবে–

TC = Total cholesterol

TG = triglycerides

Rosuvastatin:-

Tablet 1:Rosu 5mg (AS A Rosuvastatin Calcium AS A Other Anti-anginal & Anti-ischaemic drugs, Statins).

Indications of Tablet :Rosu 5mg (AS A Rosuvastatin Calcium AS A Other Anti-anginal & Anti-ischaemic drugs, Statins).

Rosu tablet is indicated for:

Patients with primary hyperlipidemia and mixed dyslipidemia as an adjunct to diet to reduce elevated total-C, LDL-C, ApoB, non HDL-C and TG levels and to increase HDL-C.
Patients with hypertriglyceredemia as an adjunct to diet.
Patients with primary dysbetalipoproteinemia (Type III hyperlipoproteinemia) as an adjunct to diet.
Patients with homozygous familial hypercholesterolemia (HoFH) to reduce LDL-C, total-C, and ApoB.
Slowing the progression of atherosclerosis as part of a treatment strategy to lower total-C and LDL-C as an adjunct to diet.
Pediatric patients 10 to 17 years of age with heterozygous familial hypercholesterolemia (HeFH) to reduce elevated total-C, LDL-C and ApoB after failing an adequate trial of diet therapy.
Risk reduction of Myocardial Infarction (MI), stroke and arterial revascularization procedures in patients without clinically evident CHD, but with multiple risk factors.

Pharmacology of Tablet :Rosu 5mg (AS A Rosuvastatin Calcium AS A Other Anti-anginal & Anti-ischaemic drugs, Statins).

Rosuvastatin is a selective and competitive inhibitor of HMG-CoA reductase, the rate-limiting enzyme that converts 3-hydroxy-3-methyl glutaryl coenzyme A to mevalonate, a precursor of cholesterol. Rosuvastatin produces its lipid-modifying effects in two ways. First, it increases the number of hepatic LDL receptors on the cell surface to enhance uptake and catabolism of LDL. Second, Rosuvastatin inhibits hepatic synthesis of VLDL, which reduces the total number of VLDL and LDL particles.

Dosage & Administration of Tablet :Rosu 5mg (AS A Rosuvastatin Calcium AS A Other Anti-anginal & Anti-ischaemic drugs, Statins).

Heterozygous Familial Hypercholesterolemia in Pediatric Patients (10 to 17 years of age): The usual dose range of Rosuvastatin is 5-20 mg/day; the maximum recommended dose is 20 mg/day (doses greater than 20 mg have not been studied in this patient population). Doses should be individualized according to the recommended goal of therapy. Adjustments should be made at intervals of 4 weeks or more.

Very High Cholesterol and High Risk of Ml or Stroke: 40 mg once daily.

Homozygous Familial Hypercholesterolemia: The recommended starting dose of Rosuvastatin is 20 mg once daily. Response to therapy should be estimated from preapheresis LDL-C levels.

Dosage in Asian Patients: Initiation of Rosuvastatin therapy with 5 mg once daily should be considered for Asian patients

Use with Cyclosporine, Lopinavir/Ritonavir or Atazanavir/Ritonavir: In patients taking Cyclosporine, the dose of Rosuvastatin should be limited to 5 mg once daily. In patients taking a combination of Lopinavir and Ritonavir or Atazanavir and Ritonavir, the dose of Rosuvastatin should be limited to 10 mg once daily.

Concomitant Lipid-Lowering Therapy: The risk of skeletal muscle effects may be enhanced when Rosuvastatin is used in combination with Niacin or Fenofibrate; a reduction in Rosuvastatin dosage should be considered in this setting. Combination therapy with Gemfibrozil should be avoided because of an increase in Rosuvastatin exposure with concomitant use; if Rosuvastatin is used in combination with Gemfibrozil, the dose of Rosuvastatin should be limited to 10 mg once daily.

Dosage in Patients with Severe Renal Impairment: For patients with severe renal impairment (ClCr<30 mL/min/1.73 m²) not on hemodialysis, dosing of Rosuvastatin should be started at 5 mg once daily and not exceed 10 mg once daily.

Interaction of Tablet :Rosu 5mg (AS A Rosuvastatin Calcium AS A Other Anti-anginal & Anti-ischaemic drugs, Statins).

Remarkable drug interactions of Rosu are-

Cyclosporine: Combination increases Rosu exposure. Rosu dose should be limited to 5 mg once daily.
Gemfibrosil: Combination should be avoided. If used together, Rosu dose should be limited to 10 mg once daily.
Lopinavir/Ritonavir or atazanavir/ritonavir: Combination increases Rosu exposure. Rosu dose should be to 10 mg once daily.
Coumarin anticoagulants: Combination prolongs international normalized ratio (INR). Stable INR should be achieved prior to starting Rosu. INR should be monitored frequently until stable upon initiation or alteration of Rosu therapy.
Concomitant lipid-lowering therapies: Use with fibrates and niacin products may increase the risk of skeletal muscle effects.

Contraindications of Tablet :Rosu 5mg (AS A Rosuvastatin Calcium AS A Other Anti-anginal & Anti-ischaemic drugs, Statins).

Rosuvastatin is contraindicated if-

Known hypersensitivity to product components
Liver disease, which may include unexplained persistent elevations in hepatic transaminase levels
Pregnant women and women who may become pregnant
Nursing mothers

Side Effects of Tablet :Rosu 5mg (AS A Rosuvastatin Calcium AS A Other Anti-anginal & Anti-ischaemic drugs, Statins).

Rosu is generally well tolerated. The most frequent adverse events thought to be related to Rosu were headache, myalgia, constipation, asthenia, abdominal pain and nausea.

Pregnancy & Lactation of Tablet :Rosu 5mg (AS A Rosuvastatin Calcium AS A Other Anti-anginal & Anti-ischaemic drugs, Statins).

Rosuvastatin should be administered to women of childbearing age only when such patients are highly unlikely to conceive and have been informed of the potential hazards. If the patient becomes pregnant while taking this drug, therapy should be discontinued immediately. It is not known whether Rosuvastatin is excreted in human milk, but a small amount of another drug in this class does pass into breast milk.

Precautions & Warnings of Tablet :Rosu 5mg (AS A Rosuvastatin Calcium AS A Other Anti-anginal & Anti-ischaemic drugs, Statins).

Rosu should be prescribed with caution in patients with predisposing factors for myopathy (e.g., age >65 years, inadequately treated hypothyroidism, renal impairment). The risk of myopathy during treatment with Rosu may be increased with concurrent administration of some other lipid-lowering therapies (Fibrates or Niacin), Gemfibrozil, Cyclosporine, Lopinavir/Ritonavir, or Atazanavir/Ritonavir. Rosu therapy should be discontinued if markedly elevated creatinine kinase levels occur or myopathy is diagnosed or suspected. Rosu therapy should also be temporarily withheld in any patient with an acute, serious condition suggestive of myopathy or predisposing to the development of renal failure secondary to rhabdomyolysis (e.g., sepsis, hypotension, dehydration, major surgery, trauma, severe metabolic, endocrine, and electrolyte disorders, or uncontrolled seizures). It is recommended that liver enzyme tests be performed before and at 12 weeks following both the initiation of therapy and any elevation of dose, and periodically (e.g., semiannually) thereafter.

Overdose Effects of Tablet :Rosu 5mg (AS A Rosuvastatin Calcium AS A Other Anti-anginal & Anti-ischaemic drugs, Statins).

There is no specific treatment in the event of overdose. In the event of overdose, the patient should be treated symptomatically and supportive measures instituted as required. Hemodialysis does not significantly enhance clearance of Rosu.

Therapeutic Class of Tablet :Rosu 5mg (AS A Rosuvastatin Calcium AS A Other Anti-anginal & Anti-ischaemic drugs, Statins).

Other Anti-anginal & Anti-ischaemic drugs, Statins

Common Questions about Rosu 5 mg Tablet

What is Rosu 5 mg Tablet?

Rosu 5 mg Tablet is a HMG-CoA reductase inhibitor drug which is helpful in lowering the cholesterol level and triglycerides in the body.

What are the uses of Rosu 5 mg Tablet?

Rosu 5 mg Tablet is useful against the conditions like Hyperlipidemia, Hypertriglyceridemia, Type 3 Hyperlipoproteinemia and Stroke.

What are the side effects of Rosu 5 mg Tablet?

Side effects of Rosu 5 mg Tablet include Muscle pain, Weakness, Headache and Abdominal pain.

For how long should I take Rosu 5 mg Tablet?

Rosu 5 mg Tablet should be taken till you see improvement in your medical condition. Follow your doctor’s instructions to know the duration for Rosu 5 mg Tablet.

Does Rosu 5 mg Tablet cause weight gain?

Weight gain is a very rare side effect of Rosu 5 mg Tablet. This medication does not lead to weight gain and in case you are observing this symptom, please consult a doctor for diagnosis.

Does Rosu 5 mg Tablet make you tired?

Tiredness and fatigue is a common side effect of Rosu 5 mg Tablet however, the exact reason behind it is still not known. Consult a doctor if it persists for a longer duration of time.

Should Rosu 5 mg Tablet be taken at night?

Rosu 5 mg Tablet is not mandatory to take Rosu 5 mg Tablet at night. You can take it in the morning too, however, it should be consumed once a day only. Ideally, you must follow your doctor’s instructions regarding the dosage.

What foods should be avoided when taking Rosu 5 mg Tablet?

Avoid eating junk food and foods that are high in calories as they can increase the cholesterol levels. You must eat only a low-cholesterol diet during the course of Rosu 5 mg Tablet treatment.

How do I know whether Rosu 5 mg Tablet is beneficial for me or not?

If you start noticing improvement in your condition, then Rosu 5 mg Tablet is beneficial for you. In case, you do not see any positive effects of Rosu 5 mg Tablet or experience adverse side effects after consuming this medicine, then consult a doctor to know a safer substitute of Rosu 5 mg Tablet.

Can Rosu 5 mg Tablet cause memory loss?

Memory loss is a very unusual side effect that can occur. If this symptom occurs, stop taking this medicine and consult a doctor immediately.

Is it true that Rosu 5 mg Tablet can cause diabetes?

This medicine does not cause diabetes, however, if you already are at higher risk of having this disorder, then this medicine can enhance the risk factor by increasing the blood sugar levels. In such a case, regular monitoring of blood sugar level is mandatory.

Can I take alcohol with Rosu 5 mg Tablet?

Do not take alcohol during the course of treatment with this medicine as it can increase the risk of having liver problems. Also, alcohol can increase the levels of triglyceride levels in the body.

Can Rosu 5 mg Tablet cause muscle problems or muscle injury?

Muscle pain or any other problem associated with muscles is the most common side effect of this medicine. Consult your doctor if this side effect is causing discomfort in doing day to day activities.

Quick Tips

Rosu 5 mg Tablet treats high cholesterol by lowering “bad” cholesterol (LDL) and triglycerides (fats). It should be taken in addition to regular exercise and low-fat diet.
In general, Rosu 5 mg Tablet is safe. It may cause diarrhea, gas or an upset stomach. If any of these happen to you, take it with food.
Inform your doctor if you experience fatigue, muscle weakness or muscle pain.
Your doctor may check your liver function before starting the treatment and regularly thereafter. Inform your doctor if you notice signs of liver problems such as stomach pains, unusually dark urine or yellowing of skin or eyes.
Inform your doctor if you have kidney disease, liver disease or diabetes before starting treatment with this medicine. If you are diabetic, monitor your blood sugar level regularly as Rosu 5 mg Tablet may cause an increase in your blood sugar level.
Do not take Rosu 5 mg Tablet if you are pregnant, planning a pregnancy or breastfeeding.

Atorvastatin:-

Tablet 2:-Atova 10mg (AS A Atorvastatin Calcium AS A Other Anti-anginal & Anti-ischaemic drugs, Statins).

Indications of Tablet :-Atova 10mg (AS A Atorvastatin Calcium AS A Other Anti-anginal & Anti-ischaemic drugs, Statins).

Atova is indicated as an adjunct to diet to reduce elevated total cholesterol, LDL cholesterol, apolipoprotein B (Apo-B) and triglycerides levels in following diseases when response to diet and other non-pharmacological measures is inadequate.

To reduce total cholesterol and LDL cholesterol in patients with heterozygous and homozygous familial hypercholesterolemia.
To reduce elevated cholesterol and triglycerides in patient with mixed dyslipidemia (Fredrickson Type Ia and Ib).
For the treatment of patients with elevated serum triglyceride levels in hypertriglyceridaemia (Fredrickson Type IV).
For the treatment of patients with dysbetalipoproteinaemia (Fredrickson Type III).
To reduce cardiac ischaemic events in patients with asymptomatic or mild to moderate symptomatic coronary artery disease with elevated LDL-cholesterol level.
To reduce total and LDL-cholesterol concentrations patients with hypercholesterolemia associated with or exacerbated by diabetes mellitus or renal transplantation.

Pharmacology of Tablet :-Atova 10mg (AS A Atorvastatin Calcium AS A Other Anti-anginal & Anti-ischaemic drugs, Statins).

Atorvastatin is a selective inhibitor of HMG-CoA reductase. This enzyme is the rate-limiting enzyme responsible for the conversion of HMG-CoA to mevalonate, a precursor of sterols, including cholesterol. Atorvastatin lowers plasma cholesterol and lipoprotein levels by inhibiting HMG-CoA reductase and cholesterol synthesis in the liver and increases the number of hepatic LDL receptors on the cell surface for enhanced uptake and catabolism of LDL.

Absorption: Atorvastatin is rapidly absorbed after oral administration; maximum plasma concentrations occur within 1 to 2 hours. Extent of absorption increases in proportion to Atorvastatin dose. The absolute bioavailability of Atorvastatin (parent drug) is approximately 14% and the systemic availability of HMG-CoA reductase inhibitory activity is approximately 30%.

Distribution: Mean volume of distribution of Atorvastatin is approximately 381 liters. Atorvastatin is 98% bound to plasma proteins. A blood/plasma ratio of approximately 0.25 indicates poor drug penetration into red blood cells. Based on observations in rats, Atorvastatin is likely to be secreted in human milk.

Metabolism: Atorvastatin is extensively metabolized to ortho- and parahydroxylated derivatives and various beta-oxidation products. In vitro inhibition of HMG-CoA reductase by ortho- and parahydroxylated metabolites is equivalent to that of Atorvastatin. Approximately 70% of circulating inhibitory activity for HMG-CoA reductase is attributed to active metabolites. In vitro studies suggest the importance of Atorvastatin metabolism by cytochrome P450 3A4, consistent with increased plasma concentrations of Atorvastatin in humans following coadministration with erythromycin, a known inhibitor of this isozymes. In animals, the ortho-hydroxy metabolite undergoes further glucuronidation.

Excretion: Atorvastatin and its metabolites are eliminated primarily in bile following hepatic and/or extra-hepatic metabolism; however, the drug does not appear to undergo enterohepatic recirculation. Mean plasma elimination half-life of Atorvastatin in humans is approximately 14 hours, but the half-life of inhibitory activity for HMG-CoA reductase is 20 to 30 hours due to the contribution of active metabolites. Less than 2% of a dose of Atorvastatin is recovered in urine following oral administration.

Dosage & Administration of Tablet :-Atova 10mg (AS A Atorvastatin Calcium AS A Other Anti-anginal & Anti-ischaemic drugs, Statins).

Primary hypercholesterolaemia and combined hyperlipidaemia-

Adults: Usually 10 mg once daily; if necessary, may be increased at intervals of at least 4 weeks to max. 80 mg once daily.
Child (10-18 years): Initially 10 mg once daily, increased if necessary at intervals of at least 4 weeks to usual max. 20 mg once daily.

Familial hypercholesterolaemia-

Adults: Initially 10 mg daily, increased at intervals of at least 4 weeks to 40 mg once daily; if necessary, further increased to max. 80 mg once daily (or 40 mg once daily combined with anion-exchange resin in heterozygous familial hypercholesterolaemia).
Child (10-18 years): Initially 10 mg once daily, increased if necessary at intervals of at least 4 weeks to usual max. 80 mg once daily.

Prevention of cardiovascular events-

Adults: Initially 10 mg once daily adjusted according to response.

Another guideline:

The patient should be placed on a standard cholesterol-lowering diet before receiving Atorvastatin and should continue on this diet during treatment with Atorvastatin. The recommended starting dose of Atorvastatin is 10 or 20 mg once daily. Patients who require a large reduction in LDL-C (more than 45%) may be started at 40 mg once daily. The dosage range of Atorvastatin is 10 to 80 mg once daily. Atorvastatin can be administered as a single dose at any time of the day, with or without food. After initiation of Atorvastatin lipid levels should be analyzed within 2 to 4 weeks and dosage adjusted accordingly.

In hypercholesterolemia in Pediatric Patients (10-17 years of age) the recommended starting dose of Atorvastatin is 10 mg/day; the maximum recommended dose is 20 mg/day (doses greater than 20 mg have not been studied in this patient population). Doses should be individualized according to the recommended goal of therapy. Adjustments should be made at intervals of 4 weeks or more.

Interaction of Tablet :-Atova 10mg (AS A Atorvastatin Calcium AS A Other Anti-anginal & Anti-ischaemic drugs, Statins).

The risk of myopathy during treatment with drugs of this class is increased with concurrent administration of cyclosporine, fibric acid derivatives, niacin (nicotinic acid), erythromycin, azole antifungals.

Antacid: When atorvastatin and antacid suspension were coadministered, plasma concentrations of atorvastatin decreased approximately 35%. However, LDL-C reduction was not altered.

Colestipol: Plasma concentrations of atorvastatin decreased approximately 25% when colestipol and atorvastatin were coadministered. However, LDL-C reduction was greater when atorvastatin and colestipol were coadministered than when either drug was given alone.

Digoxin: When multiple doses of atorvastatin and digoxin were coadministered, steady-state plasma digoxin concentrations increased by approximately 20%. Patients taking digoxin should be monitored appropriately.

Erythromycin: In healthy individuals, plasma concentrations of atorvastatin increased approximately 40% with coadministration of atorvastatin and erythromycin, a known inhibitor of cytochrome P450 3A4.

Oral Contraceptives: Coadministration of atorvastatin and an oral contraceptive increased AUC values for norethindrone and ethinyl estradiol by approximately 30% and 20%. These increases should be considered when selecting an oral contraceptive for a woman taking atorvastatin.

Warfarin: Atova had no clinically significant effect on prothrombin time when administered to patients receiving chronic warfarin treatment.

Contraindications of Tablet :-Atova 10mg (AS A Atorvastatin Calcium AS A Other Anti-anginal & Anti-ischaemic drugs, Statins).

Atorvastatin should not be used in patient with hypersensitivity to any component of this medication. Atorvastatin is contraindicated in active liver disease or unexplained persistent elevations of serum transaminases. It is also contraindicated in patient with history of serious adverse reaction to prior administration of HMG-CoA reductase inhibitors.

Side Effects of Tablet :-Atova 10mg (AS A Atorvastatin Calcium AS A Other Anti-anginal & Anti-ischaemic drugs, Statins).

Atova is generally well-tolerated. The most frequent side effects related to Atova are constipation, flatulence, dyspepsia, abdominal pain. Other side effects includes infection, headache, back pain, rash, asthenia, arthralgia, myalgia.

Pregnancy & Lactation of Tablet :-Atova 10mg (AS A Atorvastatin Calcium AS A Other Anti-anginal & Anti-ischaemic drugs, Statins).

Pregnancy: Atorvastatin is contraindicated during pregnancy. Safety in pregnant women has not been established. No controlled clinical trials with atorvastatin have been conducted in pregnant women. Rare reports of congenital anomalies following intrauterine exposure to HMG-CoA reductase inhibitors have been received. Animal studies have shown toxicity to reproduction. Maternal treatment with atorvastatin may reduce the fetal levels of mevalonate which is a precursor of cholesterol biosynthesis. Atorvastatin should not be used in women who are pregnant, trying to become pregnant or suspect they are pregnant. Treatment with atorvastatin should be suspended for the duration of pregnancy or until it has been determined that the woman is not pregnant

Lactation: It is not known whether atorvastatin or its metabolites are excreted in human milk. In rats, plasma concentrations of atorvastatin and its active metabolites are similar to those in milk. Because of the potential for serious adverse reactions, women taking atorvastatin should not breastfeed their infants. Atorvastatin is contraindicated during breastfeeding.

Precautions & Warnings of Tablet :-Atova 10mg (AS A Atorvastatin Calcium AS A Other Anti-anginal & Anti-ischaemic drugs, Statins).

Liver effects: Liver function tests should be performed before the initiation of treatment and periodically thereafter. Atova should be used with caution in patients who consume substantial quantities of alcohol or have a history of liver disease. Atova therapy should be discontinued if markedly elevated CPK levels occur or myopathy is diagnosed or suspected.

Use in Special Populations of Tablet :-Atova 10mg (AS A Atorvastatin Calcium AS A Other Anti-anginal & Anti-ischaemic drugs, Statins).

Geriatric: Plasma concentrations of Atova are higher (approximately 40% for Cmax and 30% for AUC) in healthy elderly subjects (age 65 years) than in young adults. Clinical data suggest a greater degree of LDL-lowering at any dose of drug in the elderly patient population compared to younger adults.

Pediatric: Pharmacokinetic data in the pediatric population are not available.

Gender: There is no clinically significant difference in LDL-C reduction with Atova between men and women.

Renal Insufficiency: Renal disease has no influence on the plasma concentrations or LDL-C reduction of Atova; thus, dose adjustment in patients with renal dysfunction is not necessary.

Hemodialysis: Hemodialysis is not expected to significantly enhance clearance of Atova since the drug is extensively bound to plasma proteins.

Hepatic Insufficiency: In patients with chronic alcoholic liver disease, plasma concentrations of Atova are markedly increased.

Overdose Effects of Tablet :-Atova 10mg (AS A Atorvastatin Calcium AS A Other Anti-anginal & Anti-ischaemic drugs, Statins).

Specific treatment is not available for atorvastatin overdose. The patient should be treated symptomatically and supportive measures instituted, as required. Liver function tests should be performed and serum CK levels should be monitored. Due to extensive atorvastatin binding to plasma proteins, hemodialysis is not expected to significantly enhance atorvastatin clearance.

Therapeutic Class of Tablet :-Atova 10mg (AS A Atorvastatin Calcium AS A Other Anti-anginal & Anti-ischaemic drugs, Statins).

Other Anti-anginal & Anti-ischaemic drugs, Statins

Common Questions about Atova 10 mg Tablet

What is Atova 10 mg Tablet?

Atova 10 mg Tablet is a selective inhibitor of HMG-CoA reductase. It is used to avoid heart attacks and Primary Hypercholesterolemia. It is also used to treat conditions such as Mixed Dyslipidemia and Hypertriglyceridemia.

How should I take Atova 10 mg Tablet?

Atova 10 mg Tablet should be taken by mouth once daily, at the same time each day. It can be taken with or without food.

What are the uses of Atova 10 mg Tablet?

Atova 10 mg Tablet is used for the treatment of diseases like Mixed Dyslipidemia and Hypertriglyceridemia. Besides these, it can also be used to treat conditions like heart attacks and Primary Hypercholesterolemia.

What are the Side Effects of Atova 10 mg Tablet?

This is a list of possible side-effects which may occur due to the constituting ingredients of Atova 10 mg Tablet. These side-effects have been observed and not necessarily occur. Some of these side-effects may be serious. These include cough, muscle pain, breathing difficulty and running nose.

What are the instructions for storage and disposal Atova 10 mg Tablet?

Atova 10 mg Tablet should be stored at room temperature, away from heat and direct light. Keep it away from the reach of children and pets.

Is Atova 10 mg Tablet used for lowering cholesterol?

Atova 10 mg Tablet comes under the class of drugs termed as statins and helps in decreasing the level of lipids or fats. It is used to lower cholesterol and triglycerides present in the blood. However, you must take a cholesterol-lowering diet during the course of treatment.

Will taking Atova 10 mg Tablet increase my risk of diabetes?

If you have type 2 diabetes, then consuming Atova 10 mg Tablet can slightly affect your health as Atova 10 mg Tablet is known to increase the blood sugar levels. In such a case, regular monitoring of blood sugar level during the course of treatment is important.

For how long do I need to take Atova 10 mg Tablet? Is it safe for long-term use?

Atova 10 mg Tablet should be taken for a duration that a doctor has prescribed it. If you stop taking this medicine without completing the full course, then it can worsen your condition. This medicine is considered safe for long term use if you take it exactly as directed by the doctor.

Does Atova 10 mg Tablet cause weight loss?

No studies report that Atova 10 mg Tablet can cause weight loss. This is a very unusual side effect. If you encounter weight loss after the course of medication, then doctor consultation is suggested.

Can I stop taking Atova 10 mg Tablet?

Do not stop taking Atova 10 mg Tablet without informing your doctor. Completing the course of medication is necessary or it can worsen your condition.

Does Atova 10 mg Tablet cause memory loss?

Memory loss is a very rare side effect of Atova 10 mg Tablet. You must consult a doctor if you experience it.

Does Atova 10 mg Tablet make you tired?

Atova 10 mg Tablet can make you feel tired. Although the exact reason behind this is still not known.

Can Atova 10 mg Tablet be prescribed to children?

Atova 10 mg Tablet should be used by adults. Children above 10 years of age can also use it however caution must be exercised. Atova 10 mg Tablet should not be given to children who are less than 10 years old.

Is Atova 10 mg Tablet a blood thinner?

Atova 10 mg Tablet does not cause thinning of the blood. This medication lowers cholesterol and prevents the chances of stroke and heart attack.

Quick Tips

In general, Atova 10 mg Tablet is safe. It may cause diarrhea, gas or an upset stomach. If any of these happen to you, take it with food.
Inform your doctor if you experience fatigue, muscle weakness or muscle pain.
Your doctor may check your liver function before starting the treatment and regularly thereafter. Inform your doctor if you notice signs of liver problems such as stomach pains, unusually dark urine or yellowing of skin or eyes.
Inform your doctor if you have kidney disease, liver disease or diabetes before starting treatment with this medicine. If you are diabetic, monitor your blood sugar level regularly as Atova 10 mg Tablet may cause an increase in your blood sugar level.
Do not take Atova 10 mg Tablet if you are pregnant, planning a pregnancy or breastfeeding.

সিনারিও-

জামশেদ ৫৭ বছর বয়স, Fatty liver grade 1 নিয়ে আসছে,

তার আগে থেকে Hypertension + IHD আছে– Lipid profile করা হলো–

HDL = 45 mg /dl (Ref: Range: >60

LDL = 150 mg/dl ( Normal <130)

TC = 300 mg /Dl (Normal <150)

TG = 600 mg/dl (Normal 150-250)

Lipid management ki hobe ?

Raiyyan Tahsan Date:-24-01-2025 Friday Time:-7-58-45PM

Raiyyan Tahsan

Raiyyan Tahsan