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Dermatology Case No 16.Scalp Folliculitis

সিনারিও- রাশেদ ২৮ বছর বয়স, ১ মাস থেকে তার মাথায় itching + Multiple pustular lesion — লেশন গুলিতে মাঝেমধ্যে পেইন হয়, এইটার ডায়াগনোসিস ও চিকিৎসা কি?

উত্তর-

Dx: Scalp folliculitis,

Scalp folliculitis হচ্ছে Hair follicle এর inflammation, এই inflammation টা যেসব জায়গায় Hair থাকে, সেখানে হতে পারে, যেমন মুখের মধ্যে হলে folliculitis Barbae বলে,

এখানে ২ ধরণের Organism Responsible,

১. স্কিন ফ্লোরা staphylococcus aureus

সাথে কিছু ফাংগাস থাকে, বিশেষ করে malassezia purpur,. অর্থাৎ এইটা একটা Mixed infection,

ব্যাকটেরিয়া + ফাংগাস দুই ধরনের অর্গানিজম দিয়ে এই ইনফেকশন হয়-

এই ইনফেকশনে খুবই discomfort feel হয়–

কারো কারো এইটা recurrent হয়,

Diabetes patient ও immuno compromised patient দের বেশি হয়, যারা personal hygiene maintain করেনা, নিয়মিত গোসল করেনা, তাদের ক্ষেত্রেও হতে পারে-

এখানে চিকিৎসা হিসাবে Topical antibiotics, Topical antifungal, and short course এর জন্য Topical mild steroid দেওয়া হবে to reduce discomfort and reduce inflammation.. সাথে Itching এর জন্য এন্টি হিসটামিন দেওয়া হয়- ওরাল এন্টিবায়োটিক ডক্সিসাইক্লিন দেওয়া হয় ১ মাসের জন্য-

এখন উপরের সিনারিওতে পেশেন্ট এর চিকিৎসা হবে-

1.. Fusicort cream  (2%+1%) 10gm Tube (( Fusidic acid + Hydrocortisone)   AS A Hydrocortisone & Combined preparations).

Indications of  Fusicort cream :- (2%+1%) 10gm Tube (( Fusidic acid + Hydrocortisone)   AS A Hydrocortisone & Combined preparations).

Fusicort is indicated in the following skin diseases where bacterial infections are already present or suspected to occur-

  • Primary irritant dermatitis
  • Contact allergic dermatitis
  • Eczema (atopic, infantile, discoid, stasis)
  • Seborrhoeic dermatitis

Pharmacology of  Fusicort cream :- (2%+1%) 10gm Tube (( Fusidic acid + Hydrocortisone)   AS A Hydrocortisone & Combined preparations).

Fusidic Acid BP 2% & Hydrocortisone Acetate BP 1% combination cream contains the potent topical antibacterial action of Fusidic Acid with the anti-inflammatory & anti-pruritic effects of Hydrocortisone Acetate. When applied topically, Fusidic Acid is effective against Staphylococci, Streptococci, Corynebacteria, Neisseria and certain Clostridia & Bacteroides. Fusidic Acid is an antimicrobial agent that acts as an inhibitor of protein synthesis in the microorganism. It interferes with translocation step by stabilizing the ribosome-guanosine diphosphate elongation factor G-complex. This prevents binding of aminoacyl t-RNA to the ribosome and thereafter stops transfer of additional amino acids to the growing polypeptide. In humans, Hydrocortisone is the principal naturally occurring glucocorticosteroid. In pharmaceutical dosage, its main action is to reduce the response of the skin to injury (i.e. anti-in ammatory). It also has immuno suppressant & anti-mitotic actions.

Dosage & Administration of  Fusicort cream :- (2%+1%) 10gm Tube (( Fusidic acid + Hydrocortisone)   AS A Hydrocortisone & Combined preparations).

Adults: This Cream should be applied 3 times daily and gently massaged onto the affected areas for 2 weeks. A shorter course should be considered if symptoms improve.

Children: It is not recommended in children under 3 years of age.

Interaction of  Fusicort cream :- (2%+1%) 10gm Tube (( Fusidic acid + Hydrocortisone)   AS A Hydrocortisone & Combined preparations).

If absorbed systemically, Fusidic Acid may inhibit the metabolism of drugs that undergo extensive biotransformation in the liver, but no evidence for this is available. No hazardous drug interactions are reported with topical Hydrocortisone Acetate.

Contraindications of  Fusicort cream :- (2%+1%) 10gm Tube (( Fusidic acid + Hydrocortisone)   AS A Hydrocortisone & Combined preparations).

This preparation is contraindicated in patients with hypersensitivity to Fusidic Acid, Hydrocortisone Acetate, or other components of the cream. As with other topical antibiotic/corticosteroid combination preparations, it is contraindicated in bacterial infections due to non-susceptible organisms, fungal infections, tuberculosis of the skin, syphilitic skin infections, chicken pox, eruptions following vaccinations and viral diseases of the skin in general.

Side Effects of  Fusicort cream :- (2%+1%) 10gm Tube (( Fusidic acid + Hydrocortisone)   AS A Hydrocortisone & Combined preparations).

Fusidic Acid has been reported to cause mild irritation at the application site, but did not usually require discontinuation of therapy. Reports of hypersensitivity reactions have been rare. Adverse effects are generally local and include: dryness, itching, burning, local irritation, striae, skin atrophy, atrophy of subcutaneous tissues, telangiectasia, hypertrichosis, change in pigmentation and secondary infection. If applied to the face, acne rosacea or perioral dermatitis can occur.

Pregnancy & Lactation of  Fusicort cream :- (2%+1%) 10gm Tube (( Fusidic acid + Hydrocortisone)   AS A Hydrocortisone & Combined preparations).

The safety of Fusidic Acid and/or topical Hydrocortisone Acetate during pregnancy or lactation has not been established. The use of this cream during pregnancy or lactation requires that the potential bene ts be weighed against the risks to the fetus or nursing infant.

Precautions & Warnings of  Fusicort cream :- (2%+1%) 10gm Tube (( Fusidic acid + Hydrocortisone)   AS A Hydrocortisone & Combined preparations).

Fusidic Acid and Hydrocortisone Acetate should not be used in or near the eye because of the possibility of conjuctival irritation by Fusidic Acid. When used under occlusive dressing, over extensive areas or on the face, scalp, axillae and scrotum, suffcient absorption may occur, giving rise to adrenal suppression and other systemic effects.

Use in Special Populations of  Fusicort cream :- (2%+1%) 10gm Tube (( Fusidic acid + Hydrocortisone)   AS A Hydrocortisone & Combined preparations).

Use in children: Clinical trials with Fusidic Acid & Hydrocortisone Acetate have not demonstrated any increased incidence of adverse effects in children 3 years and over. There are no data from randomized, controlled clinical trials on the safety and efficacy of Fusicort in children under 3 years of age.

Therapeutic Class of  Fusicort cream :- (2%+1%) 10gm Tube (( Fusidic acid + Hydrocortisone)   AS A Hydrocortisone & Combined preparations).

Hydrocortisone & Combined preparations

দিনে ২ বার (৭-১০ দিন)

অথবা [[ Clindac Lotion দিনে ৩ বার (৭-১৪ দিন)

Lotion 2:-Clindacin 1% 25ml Bottle (AS A Clindamycin Macrolides).

Indications of Lotion :-Clindacin 1% 25ml Bottle (AS A Clindamycin Macrolides).

Clindacin lotion is indicated in the treatment of acne vulgaris. Other uses of topical Clindacin lotion are:

  • Skin infections such as erythrasma caused by Corynebacterium minutissimum; rosacea, periorificial dermatitis, folliculitis, stasis, chronic lymphaedema and familial pemphigus.
  • Dermal ulcers.

Pharmacology of Lotion :-Clindacin 1% 25ml Bottle (AS A Clindamycin Macrolides).

Clindamycin is a lincosamide antibiotic used in the treatment of infections caused by susceptible microorganisms. Clindamycin is a semisynthetic antibiotic derived from lincomycin. It has antiacne and antibacterial activity. It binds with the 50s subunit of the bacterial ribosome and inhibits the early stage of protein synthesis. It is highly potent against gram positive and anaerobic bacteria.

Microbiology: Aerobic gram-positive cocci, including: Staphylococcus aureus, Staphylococcus epidermidis (penicillinase and non-penicillinase producing strains), Streptococci, Pneumococci. Anaerobic gram-negative bacilli, including: Bacteroides species, Fusobacterium species. Anaerobic gram-positive non-spore forming bacilli, including: Propionibacterium species, Eubacterium species, Actinomyces species. Anaerobic and microaerophilic gram-positive cocci, including: Peptococcus species, Peptostreptococcus species, Microaerophilic streptococci, C. perfringes

Dosage & Administration of Lotion :-Clindacin 1% 25ml Bottle (AS A Clindamycin Macrolides).

At first, wash the face or affected area gently with warm water or soap. When the skin is completely dried (about 30 minutes later) apply a thin film of Clindamycin lotion to the entire affected area twice daily. The Applied area should not be washed within 3 hours. Noticeable improvement is usually seen after about 6 weeks. However, 8 to 12 weeks of treatment may be required for maximum benefit. Eye, lip or nose contact should be avoided while applying Clindamycin lotion.

Interaction of Lotion :-Clindacin 1% 25ml Bottle (AS A Clindamycin Macrolides).

Clindacin enhances the action of other neuromuscular blocking agents. Therefore, it should be used with caution in patients receiving such agents. Antagonism has been demonstrated between Clindacin and erythromycin in vitro. Because of possible clinical significance, these two drugs should not be administered concurrently.

Side Effects of Lotion :-Clindacin 1% 25ml Bottle (AS A Clindamycin Macrolides).

Side effects are usually rare. Possible side-effects may includes skin rash, itching, oily skin, dryness, erythema, burning, change in skin color, diarrhea, colitis, GI disturbance etc.

Pregnancy & Lactation of Lotion :-Clindacin 1% 25ml Bottle (AS A Clindamycin Macrolides).

There is no adequate data for safe use in pregnancy. Animal studies showed no adverse effects on the fetus. It is not known that whether Clindamycin is excreted through breast milk following topical administration. However, Clindamycin lotion can be used during lactation with caution.

Precautions & Warnings of Lotion :-Clindacin 1% 25ml Bottle (AS A Clindamycin Macrolides).

Clindacin lotion is not for oral, ophthalmic, or Intravaginal use. Avoid exposure to sunlight and sunlamps. Wear sunscreen daily.

Overdose Effects of Lotion :-Clindacin 1% 25ml Bottle (AS A Clindamycin Macrolides).

Intravaginal overdose is not possible. Accidental ingestion of the product could be accompanied by effects related to therapeutic levels of oral Clindacin.

Therapeutic Class of Lotion :-Clindacin 1% 25ml Bottle (AS A Clindamycin Macrolides).

Macrolides

Topicort cream (৭-১৪ দিন]]

Cream 3:-Topicort 1% 20gm tube (AS A Topicort Hydrocortisone Acetate AS A Other Topical corticosteroids).

Indications of Cream :Topicort 1% 20gm tube (AS A Topicort Hydrocortisone Acetate AS A Other Topical corticosteroids).

The anti-inflammatory activity of Topicort is its main therapeutic property. It also has immunosuppressant and antimitotic actions. Topicort is indicated in:

  • Primary irritant dermatitis
  • Contact allergic dermatitis
  • Eczema: atopic, infantile, discoid, stasis
  • Seborrheic dermatitis
  • Lichen simplex and pruritus ani
  • Flexural psoriasis
  • Skin irritations, itching and rashes, for example those caused by insect bites, minor thermal burns, sunburn, etc

Pharmacology Indications of Cream :Topicort 1% 20gm tube (AS A Topicort Hydrocortisone Acetate AS A Other Topical corticosteroids).

Hydrocortisone binds to the cytosolic glucocorticoid receptor. After binding the receptor the newly formed receptor-ligand complex translocates itself into the cell nucleus, where it binds to many glucocorticoid response elements (GRE) in the promoter region of the target genes. The DNA bound receptor then interacts with basic transcription factors, causing the increase in expression of specific target genes. The anti-inflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibition arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes. Specifically glucocorticoids induce lipocortin-1 (annexin-1) synthesis, which then binds to cell membranes preventing the phospholipase A2 from coming into contact with its substrate arachidonic acid. This leads to diminished eicosanoid production. The cyclooxygenase (both COX-1 and COX-2) expression is also suppressed, potentiating the effect. In other words, the two main products in inflammation Prostaglandins and Leukotrienes are inhibited by the action of Glucocorticoids. Glucocorticoids also stimulate the lipocortin-1 escaping to the extracellular space, where it binds to the leukocyte membrane receptors and inhibits various inflammatory events: epithelial adhesion, emigration, chemotaxis, phagocytosis, respiratory burst and the release of various inflammatory mediators (lysosomal enzymes, cytokines, tissue plasminogen activator, chemokines etc.) from neutrophils, macrophages and mastocytes. Additionally the immune system is suppressed by corticosteroids due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding.

Dosage & Administration Indications of Cream :Topicort 1% 20gm tube (AS A Topicort Hydrocortisone Acetate AS A Other Topical corticosteroids).

Hydrocortisone Acetate should be applied in a small quantity to the affected area 2 or 3 times daily.

Contraindications Indications of Cream :Topicort 1% 20gm tube (AS A Topicort Hydrocortisone Acetate AS A Other Topical corticosteroids).

  • Infections: bacterial, viral, fungal.
  • Skin ulcers.
  • Hypersensitivity to the preparation.

Side Effects Indications of Cream :Topicort 1% 20gm tube (AS A Topicort Hydrocortisone Acetate AS A Other Topical corticosteroids).

Topicort 1% cream is usually well-tolerated, but if signs of hypersensitivity appear, application should be stopped.

Pregnancy & Lactation Indications of Cream :Topicort 1% 20gm tube (AS A Topicort Hydrocortisone Acetate AS A Other Topical corticosteroids).

There is inadequate evidence for safety in human pregnancy. It is recommended that topical corticosteroids should not be used extensively during pregnancy. It is highly unlikely that sufficiently high blood levels of Hydrocortisone are achieved during topical therapy to reach breast milk.

Therapeutic Class of Cream :Topicort 1% 20gm tube (AS A Topicort Hydrocortisone Acetate AS A Other Topical corticosteroids).

2.. Ketoconazol shampoo (Nizoder 2%)

প্রতিদিন গোসলের সময় ৩ মাস.

Shampoo 1.Dancel 2% 100ml bottle (AS A Ketoconazol Drugs for subcutaneous and mycoses).

Indications of Shampoo:-Dancel 2% 100ml bottle (AS A Ketoconazol Drugs for subcutaneous and mycoses).

Shampoo: Dancel shampoo is indicated for the treatment and prophylaxis of infections in which the yeast Malassezia (previously called Pityrosporum) is involved, such as pityriasis versicolor (localized), seborrhoeic dermatitis and pityriasis capitis (dandruff).

Cream: Cream is used for topical application in the treatment of dermatophyte infections of the skin such as tinea corporis, tinea cruris (dhobie itch), tinea manus and tinea pedis (athlete’s foot) infections due to Trichophyton spp, Microsporon spp and Epidermophyton spp. Dancel 2% cream is also indicated for the treatment of cutaneous candidosis (including vulvitis), candidal intertrigo (sweat rash), tinea (pityriasis) versicolor and seborrhoeic dermatitis caused by Malassezia (previously called Pityrosporum) spp.

Tablet: Treatment of superficial and deep mycoses:

  • Infections of the skin, hair and nails by dermatophytes and/or yeasts (dermatomycosis, onychomycosis, perionyxis, pityriasis versicolor, chronic mucocutaneous candidiasis etc.) especially when topical treatment is difficult or not very effective, owing to involvement of large skin surfaces or to lesions affecting deeper dermal layers, nails and hairs
  • Yeast infection of the mouth (oral thrush, perleche) and the gastrointestinal tract
  • Vaginal candidiasis, especially chronic recurrent cases or cases responding poorly to topcial treatment
  • Systemic mycotic infections such as systemic candidiasis, paracoccidioidomycosis, histoplasmosis, coccidioidomycosis etc.

Maintenance treatment to prevent recurrence in systemic mycotic infections and in chronic mucocutaneous candidiasis.

Prophylactic treatment to prevent mycotic infection in patients with reduced host defenses, e.g., patients with cancer, organ transplant and burns.

Medicated bar: Medicated bar is indicated for All Kinds of Body Fungus.

Pharmacology of Shampoo:-Dancel 2% 100ml bottle (AS A Ketoconazol Drugs for subcutaneous and mycoses).

Ketoconazole interacts with 14-α-sterol demethylase, a cytochrome P-450 enzyme necessary for the conversion of lanosterol to ergosterol. This results in inhibition of ergosterol synthesis and increased fungal cellular permeability due to reduced amounts of ergosterol present in the fungal cell membrane. This metabolic inhibition also results in accumulation of 14α-methyl-3,6-diol, a toxic metabolite. The increase in membrane fluidity is also thought to produce impairment of membrane-bound enzyme systems as components become less closely packed.

Dosage & Administration of Shampoo:-Dancel 2% 100ml bottle (AS A Ketoconazol Drugs for subcutaneous and mycoses).

Shampoo: The affected areas of the skin or the scalp should be washed with ketoconazole 2% shampoo, which should be left on the skin/scalp for 3 to 5 minutes before rinsing.

Treatment:

  • Pityriasis versicolor: Once daily for 5 days.
  • Seborrhoeic dermatitis and pityriasis capitis: Twice weekly for 2 to 4 weeks.

Prophylaxis:

  • Pityriasis versicolor: Once daily for 3 days during a single treatment course before the summer.
  • Seborrhoeic dermatitis and pityriasis capitis: Once every 1 or 2 weeks.

Cream:

  • Tinea pedis: Ketoconazole cream should be applied to the affected areas twice daily. The usual duration of treatment for mild infections is 1 week. For more severe or extensive infections (e.g. involving the sole or sides of the feet) treatment should be continued until a few days after all signs and symptoms have disappeared in order to prevent relapse.
  • For other infections: Ketoconazole cream should be applied to the affected areas once or twice daily, depending on the severity of the infection. The treatment should be continued until a few days after the disappearance of all signs and symptoms. The usual duration of treatment is: tinea versicolor 2-3 weeks, tinea corporis 3-4 weeks. The diagnosis should be reconsidered if no clinical improvement is noted after 4 weeks. General measures in regard to hygiene should be observed to control sources of infection or reinfection. Seborrhoeic dermatitis is a chronic condition and relapse is highly likely.

Tablet:

  • Vaginal candidiasis: 1 tablet (200 mg) tablet twice daily for 5 days.
  • All other indications: 1 tablet (200 mg) once daily until at least one week after the symptoms have disappeared and the cultures have become negative.

Duration of Treatment-

  • Pityriasis versicolor: 1 to 6 weeks
  • Dermatomycoses: 2 to 8 weeks
  • Onychomycoses: 1 to 12 months
  • Mycoses of hair and scalp: 1 to 2 months
  • Chronic mucocutaneous candidiasis : 1 to 12 months
  • Oral mycoses: 5 to 10 days
  • Systemic candidiasis: 1 to 2 months
  • Paracoccidioidomycosis,histoplasmosis
  • and other systemic mycosis: 1 month to 2 years

Ketoconazole bar: Body Fungus: rub gently on the overall body to produce lather. Leave for 4-5 minutes. Rinse of thoroughly with water.

Contraindications of Shampoo:-Dancel 2% 100ml bottle (AS A Ketoconazol Drugs for subcutaneous and mycoses).

Contraindicated in patients with known hypersensitivity to ketoconazole.

Side Effects of Shampoo:-Dancel 2% 100ml bottle (AS A Ketoconazol Drugs for subcutaneous and mycoses).

Shampoo:  Topical treatment with Dancel shampoo 2% is generally well tolerated. As with other shampoos, a local burning sensation, itching or contact dermatitis (due to irritation or allergy) may occur on exposed areas. Oily and dry hair have been reported rarely with the use of Dancel shampoo 2%.

Cream: Commonly observed adverse reactions to Dancel cream in clinical trials were skin application site burning sensation, erythema and pruritus. Uncommon adverse reactions are application site bleeding, discomfort, dryness, inflammation, irritation, paraesthesia and reaction; bullous eruption, dermatitis contact, rash, skin exfoliation and sticky skin.

Tablet: Dancel is very well tolerated. Nausea and itching may occasionally occur. In some patients, an idosyncratic liver reaction may occur (incidence 1:10000).

Therapeutic Class of Shampoo:-Dancel 2% 100ml bottle (AS A Ketoconazol Drugs for subcutaneous and mycoses).

Drugs for subcutaneous and mycoses

3.. Cap : Doxicap 50 mg

2+0+2 (১ম দিন)

তার পর 1+0+1 (১ মাস)

3. Capsule- Doxicap 100 mg (AS A Doxycycline Hydrochloride AS A Tetracycline group of drugs.).

1+0+1 (7 days)

Indications of Capsule- Doxicap 100 mg (AS A Doxycycline Hydrochloride AS A Tetracycline group of drugs.).

Doxicap is indicated in the following infections caused by susceptible microorganisms:

  • Respiratory tract infections: Pneumonia, influenza, sinusitis, bronchitis, tonsillitis, tracheitis.
  • Gastrointestinal tract infections: Cholera, traveler’s diarrhea, shigella dysentery, acute intestinal amebiasis.
  • Chlamydial infections: Lympho-granuloma venereum, psittacosis, trachoma.
  • Sexually transmitted diseases: Non gonococcal urethritis, acute pelvic inflammatory disease, uncomplicated urethral and endocervical or rectal infections, gonorrhoea, syphilis, pyelonephritis, cystitis.
  • Other infections: Impetigo, furunculosis, inclusion conjunctivitis, brucellosis, tularemia, cellulitis, acne and Q-fever.
  • Description
  • Doxicap is a highly active broad-spectrum antibiotic of tetracycline group. It is effective against a wide range of Gram-positive and Gram-negative bacteria, spirochete, mycoplasma, rickettsia and mycobacteria. Doxicap is used as an alternate to penicillin in the treatment of gonorrhoea and syphilis. Doxicap has its main mechanism of action on protein synthesis. Inside the bacterial cell, it inhibits protein synthesis.

Pharmacology Capsule- Doxicap 100 mg (AS A Doxycycline Hydrochloride AS A Tetracycline group of drugs.).

  •  
  • Doxycycline Hydrochloride is a semisynthetic tetracycline antibiotic with broad spectrum activity. It is primarily a bacteriostatic antibiotic. It has a similar spectrum of activity to other tetracyclines but in particular is more active against Staphylococcus aureus and Nocardia. The drug is often active against penicillin-resistant strains of Staphylococcus aureus and against strains of those organisms that are resistant to other Tetracyclines. Certain Gram-negative strains of E. coli, Proteus mirabilis and Klebsiella, which are often resistant to Tetracycline, may be sensitive to Doxycycline. In addition, 70-90% of the various anaerobes are sensitive to Doxycycline and Bacteroides fragilis is more likely to be sensitive to Doxycycline than to other tetracyclines.

    Doxycycline is active against most strains of Haemophilus influenzaeand is particularly useful for infections with H. ducreyi, Actinomyces, Brucella and Vibrio cholerae. It is also active against Nocardia, Chlamydia, Mycoplasma and a wide range of Rickettsiae. Doxycycline is active against spirochetes such as Borellia recurrentis, Treponema pallidum and Treponema pertenue. It is also active against Plasmodium falciparum.

Dosage Capsule- Doxicap 100 mg (AS A Doxycycline Hydrochloride AS A Tetracycline group of drugs.).

  •  
  • Usual dose: 200 mg on first day, then 100 mg daily for 7-10 days.
    Severe infections (including refractory urinary tract infections): 200 mg daily for 10 days.
    Acne: 100 mg daily.
    Uncomplicated genital chlamydia, non-gonococcal urethritis: 100 mg twice daily for 7-21 days (14-21 days in pelvic inflammatory disease).
  •  

Administration Capsule- Doxicap 100 mg (AS A Doxycycline Hydrochloride AS A Tetracycline group of drugs.).

  •  
  • Capsules should be swallowed whole with plenty of fluid during meals while sitting or standing.
  •  

Interaction Capsule- Doxicap 100 mg (AS A Doxycycline Hydrochloride AS A Tetracycline group of drugs.).

  •  
  • Absorption of tetracyclines is impaired by antacid containing aluminium, calcium or magnesium, and iron containing preparation. Absorption of tetracyclines is also impaired by bismuth salicylate. Barbiturates, carbamazepine and phenytoin decrease half-life of doxycycline. Concurrent use of tetracyclines may render oral contraceptive less effective. Patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosages. It is advisable to avoid giving tetracyclines in conjunction with penicillin.
  • Contraindications
  • Doxycycline is contraindicated to the patients who have shown hypersensitivity to any of the tetracyclines. Doxycycline is contraindicated to the children under 8 years of age. It is also contraindicated to pregnant women and to the lactating mothers.

Side Effects Capsule- Doxicap 100 mg (AS A Doxycycline Hydrochloride AS A Tetracycline group of drugs.).

  •  
  • Nausea, vomiting, diarrhoea, skin rashes, hemolytic anaemia, eosinophilia may be reported.

Pregnancy & Lactation Capsule- Doxicap 100 mg (AS A Doxycycline Hydrochloride AS A Tetracycline group of drugs.).

  •  
  • Doxycycline should be avoided in pregnant women, because of the risk of both staining and effect on bone growth in the foetus. Doxycyclines enter breast milk, and mothers taking these drugs should not breastfeed their child.
  • Precautions & Warnings
  • The use of drugs of the tetracycline class during tooth development (last half of pregnancy, infancy and childhood to the age of 8 years) may cause permanent discoloration of teeth. Tetracyclines drugs, therefore should not be used in this age group.

Therapeutic Class Capsule- Doxicap 100 mg (AS A Doxycycline Hydrochloride AS A Tetracycline group of drugs.).

  •  
  • Tetracycline group of drugs

General Quaries:-

1.বাচ্চাদের হলে ডক্সিসাইক্লিনের বদলে কি দিব?

Answer is:-Azithromycin

2.S.Aureus er jonno B lactum group fluxocillin type er kisu ki dite hobe?

Janar jonno ask korlam.

Answer is:-doxycycline can cover all organisms.. Propionibacterium Acne ও থাকে এখানে,so aita Dile e hobe .

3.Eikhane infection er majhe steroid topicort cream keno dewa hobe?

Answer is:

To reduce inflammation and itching using as steroid topicort cream.

এক মাস পর ফলোআপ দিবেন, কারো ক্ষেত্রে ৩ মাস চিকিৎসা লাগতে পারে–

Raiyyan Tahsan Date:24-01-2025 Friday Time:1-21-35Pm

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