Melasma/মেছতা
মেছতা ত্বকের একটি সাধারণ রোগ।ত্বকের বিভিন্ন অংশে মেলানিনের প্রডাকশন বেড়ে গেলে কালো/বাদামী দাগ পড়ে যা মেছতা নামে পরিচিত।
কেন হয়?
-প্রধান কারণ জেনেটিক প্রিডিসপজিশন
-সূর্যের আলো, চুলার আগুন
-জন্মনিয়ন্ত্রণ পিল
-কসমেটিকসের প্রতিক্রিয়া
-গর্ভাবস্থায়ও হতে পারে।
কোথায় হয়?
-সাধারণত মুখমন্ডলে,তবে হাত ও বুকেও হতে পারে।
প্রকারভেদ:
-এপিডার্মাল মেলাজমা
-ডার্মাল মেলাজমা
-মিক্সড মেলাজমা(এপিডার্মাল ও ডার্মাল দুই স্তরেই হলে তাকে মিক্সড মেলাজমা বলে)
প্রতিরোধ:
•সানস্ক্রিন মেছতা প্রতিরোধে খুব কার্যকর।
•শরীরে মেলানিন বাড়ার অন্যতম কারণ হলো অক্সিডেটিভ স্ট্রেস। এটি প্রতিরোধের জন্য প্রচুর পরিমানে এন্টি অক্সিডেন্ট যুক্ত খাবার খেতে হবে
•তৈলাক্ত ভাজাপোড়া খাবার এড়িয়ে চলতে হবে।
•পর্যাপ্ত পরিমাণে পানি পান ও ঘুমাতে হবে।
•যাদের জন্মনিয়ন্ত্রণ পিল সেবনে মেছতা দেখা দেয়, তারা অন্য পন্থা অবলম্বন করবে।
•কসমেটিকস ব্যবহারে সতর্ক হতে হবে।
•গর্ভাবস্থায় যে মেছতা দেখা দেয় তা বাচ্চা জন্মের পর এমনিতেই সেরে যায়,তবুও না সারলে চিকিৎসা নিতে হবে।
চিকিৎসা :
•spot clean 4%(topical hydroquinone)
Apply 2times in a day——3month
Cream 1:Spotclen 4% 20 gm tube (As A Hydroquinone Hydroquinone Preparations.)
Indications of Cream 1:Spotclen 4% 20 gm tube (As A Hydroquinone Hydroquinone Preparations.)
Spotclen is indicated for the gradual bleaching of hyperpigmented skin conditions such as chloasma, melasma, freckles, senile lentigines and other unwanted areas of melanin hyperpigmentation. It is intended fornight-time use only since it contains no sunblocking agents.
Pharmacology of Cream 1:Spotclen 4% 20 gm tube (As A Hydroquinone Hydroquinone Preparations.)
Hydroquinone is a topical depigmentating agent that produces a reversible depigmentation of the skin by inhibiting enzymatic oxidation of tyrosine to 3,4-dihydroxyphenylalanine and suppressing melanocyte metabolic processes.
Dosage & Administration of Cream 1:Spotclen 4% 20 gm tube (As A Hydroquinone Hydroquinone Preparations.)
Hydroquinone USP 4% Cream should be applied to the affected area and rubbed in well twice daily or as directed by a physician to achieve maximum therapeutic potential. Hydroquinone Cream is intended to be used during night hours as the product contains no sunblocking agent. There is no recommended dosage for children under 12 years of age except under the advice and supervision of a physician.
Pediatric usage: Safety and effectiveness in children below the age of 12 years has not been established.
Side Effects of Cream 1:Spotclen 4% 20 gm tube (As A Hydroquinone Hydroquinone Preparations.)
No systemic adverse reactions have been reported. Occasional hypersensitivity (localized contact dermatitis) may occur in which case the medication should be discontinued and the physician notified immediately.
Therapeutic Classof Cream 1:Spotclen 4% 20 gm tube (As A Hydroquinone Hydroquinone Preparations.)
Hydroquinone Preparations
If not controlled,
Then follow 2nd line treatment.
Combination of hydroquinone+tretinoin+moderate topical steroid should be used.
Cream2. Melatrin 0.01%+4%+0.05% 30 Gm Tube ((As A Fluocinolone Acetonide+Hydroquinone+Tretinoin) AS A Hydroquinone Preparations))
Indications of Cream. Melatrin 0.01%+4%+0.05% 30 Gm Tube ((As A Fluocinolone Acetonide+Hydroquinone+Tretinoin) AS A Hydroquinone Preparations))
This cream is indicated for the short-term treatment of moderate to severe melasma of the face, after starting the treatment avoid presence of sun. Use a sunscreen of at least SPF 30 or more.
Pharmacology of Cream. Melatrin 0.01%+4%+0.05% 30 Gm Tube ((As A Fluocinolone Acetonide+Hydroquinone+Tretinoin) AS A Hydroquinone Preparations))
This cream contains three active ingredients Fluocinolone Acetonide, Hydroquinone and Tretinoin. All of them are used to treat melasma. However, the mechanism of action of the active ingredients in This cream in the treatment of melasma is unknown but Fluocinolone Acetonide is a corticosteroid for topical dermatological use and is classified therapeutically as an anti-inflammatory. Hydroquinone is classified therapeutically as a depigmenting agent, which may interrupt one or more steps in the tyrosine-tyrosinase pathway of melanin synthesis. Tretinoin is classified therapeutically as a keratolytic agent.
Dosage & Administration of Cream. Melatrin 0.01%+4%+0.05% 30 Gm Tube ((As A Fluocinolone Acetonide+Hydroquinone+Tretinoin) AS A Hydroquinone Preparations))
This cream should be applied once daily at night. It should be applied at least 30 minutes before bedtime. Gently wash the face and neck with a mild cleanser. Rinse and pat the skin dry. Apply a thin film of the cream to the hyperpigmented areas of melasma including about ½ inch of normal-appearing skin surrounding each lesion. Rub lightly and uniformly into the skin. During the day, use sunscreen and wear protective clothing. Avoid sunlight exposure. Patients may use moisturizers and/or cosmetics during the day.
Pediatric Use: The safety and effectiveness of this cream in pediatric patients have not been established.
Side Effects of Cream. Melatrin 0.01%+4%+0.05% 30 Gm Tube ((As A Fluocinolone Acetonide+Hydroquinone+Tretinoin) AS A Hydroquinone Preparations))
A very few patients may get severe allergic reactions from this cream. They may have trouble breathing or severe asthma attacks. While patients use this cream, skin may develop mild to moderate redness, peeling, burning, dryness or itching.
Therapeutic Class of Cream. Melatrin 0.01%+4%+0.05% 30 Gm Tube ((As A Fluocinolone Acetonide+Hydroquinone+Tretinoin) AS A Hydroquinone Preparations))
Hydroquinone Preparations
ঘুমানোর আধঘন্টা আগে পাতলা করে মেছতার জায়গায় এপ্লাই করবে——৮সপ্তাহ।
A/E:in 25% case skin irritation may occur and if occur, treatment should be stopped.
Raiyyan Tahsan Date:18-01-2025 Saturday Time:11-30-45 PM
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