Tablet 1:-Zimax 500mg (AS A 𝐀𝐳𝐢𝐭𝐡𝐫𝐨𝐦𝐲𝐜𝐢𝐧 Dihydrate AS A 2^ND Generation Macrolides).

Indications of Tablet :-Zimax (AS A 𝐀𝐳𝐢𝐭𝐡𝐫𝐨𝐦𝐲𝐜𝐢𝐧 Dihydrate AS A 2^ND Generation Macrolides).

Zimax is indicated for infections (caused by susceptible organisms) in lower respiratory tract infections including bronchitis and pneumonia, in upper respiratory tract infections including sinusitis and pharyngitis/tonsillitis, in otitis media, and in skin and soft tissue infections. In sexually transmitted diseases in men and women, Zimax is indicated in the treatment of non-gonococcal urethritis and cervicitis due to Chlamydia trachomatis.

Pharmacology of Tablet :-Zimax (AS A 𝐀𝐳𝐢𝐭𝐡𝐫𝐨𝐦𝐲𝐜𝐢𝐧 Dihydrate AS A 2^ND Generation Macrolides).

 

Azithromycin is acid-stable and can therefore be taken orally with no need of protection from gastric acids. It is readily absorbed; its absorption is greater on an empty stomach. Time to peak concentration in adults is 2.1 to 3.2 hours for oral dosage forms. Due to the high concentration in phagocytes, azithromycin is actively transported to the site of infection. During active phagocytosis, large concentrations of azithromycin are released. The concentration of azithromycin in the tissues can be over 50 times higher than in plasma. This is due to ion trapping and the high lipid solubility.

Azithromycin’s half-life allows a large single dose to be administered and yet maintain bacteriostatic levels in the infected tissue for several days. Following a single 500 mg dose, plasma concentrations of azithromycin declined in a polyphasic pattern with a mean apparent plasma clearance of 630 mL/min and a terminal elimination half life of 68 hours. The prolonged terminal half-life is thought to be due to extensive uptake and subsequent release of drug from tissues. Biliary excretion of azithromycin, predominantly unchanged, is a major route of elimination. Over the course of a week, approximately 6% of the administered dose appears as unchanged drug in urine.

Microbiology: Azithromycin acts by binding to the 50S ribosomal subunit of susceptible microorganisms and, thus, interfering with microbial protein synthesis. Nucleic acid synthesis is not affected. Azithromycin has been shown to be active against most isolates of the following microorganisms, both in vitro and in clinical infections:

• Aerobic and facultative gram-positive microorganisms: Staphylococcus aureus, Streptococcus agalactiae, Streptococcus pneumoniae, Streptococcus pyogenes
• Aerobic and facultative gram-negative microorganisms: Haemophilus ducreyi, Haemophilus influenzae, Moraxella catarrhalis, Neisseria gonorrhoeae
• Other microorganisms: Chlamydia pneumoniae, Chlamydia trachomatis , Mycoplasma pneumoniae , Betalactamase production should have no effect on azithromycin activity.
• Aerobic and facultative gram-positive microorganisms: Streptococci (Groups C,F,G), Viridans group streptococci
• Aerobic and facultative gram-negative microorganisms: Bordetella pertussis, Legionella pneumophila
• Anaerobic microorganisms: Peptostreptococcus species, Prevotella bivia

Dosage of Tablet :-Zimax (AS A 𝐀𝐳𝐢𝐭𝐡𝐫𝐨𝐦𝐲𝐜𝐢𝐧 Dihydrate AS A 2^ND Generation Macrolides).

 

Oral–
Adult: 500 mg once daily orally for 3 days or 500 mg once on day 1, then 250 mg once on days 2-5 for 4 days. For sexually transmitted diseases caused by Chlamydia trachomatis in adults, the dose is 1 gm given as a single dose or 500 mg once on day 1, followed by 250 mg once daily for next 2 days may also be given.

Children:

• 10 mg/kg body weight once daily for 3 days for child over 6 months
• 200 mg (1 teaspoonful) for 3 days if body weight is 15-25 kg
• 300 mg (1½ teaspoonfuls) for 3 days if body weight is 26-35 kg; 400 mg (2 teaspoonfuls) for 3 days if body weight is 36-45 kg.
• In typhoid fever, 500 mg (2½ teaspoonfuls) once daily for 7-10 days is given.

Azithromycin Injection (For IV Infusion only): The recommended dose of Azithromycin for injection for the treatment of adult patients with community-acquired pneumonia due to the indicated organisms is:

• 500 mg as a single daily dose by the intravenous route for at least two days. Intravenous therapy should be followed by Azithromycin by the oral route at a single, daily dose of 500 mg, administered as two 250-mg tablets to complete a 7 to 10-day course of therapy. The timing of the switch to oral therapy should be done at the discretion of the physician and in accordance with clinical response.
• The recommended dose of Azithromycin for the treatment of adult patients with pelvic inflammatory disease due to the indicated organisms is: 500 mg as a single daily dose by the intravenous route for one or two days. Intravenous therapy should be followed by Azithromycin by the oral route at a single, daily dose of 250 mg to complete a 7-day course of therapy. The timing of the switch to oral therapy should be done at the discretion of the physician and in accordance with clinical response. If anaerobic microorganisms are suspected of contributing to the infection, an antimicrobial agent with anaerobic activity should be administered in combination with Azithromycin.
• Safety and effectiveness of azithromycin for injection in children or adolescents under 16 years have not been established.

Dosage of Tablet :-Zimax (AS A 𝐀𝐳𝐢𝐭𝐡𝐫𝐨𝐦𝐲𝐜𝐢𝐧 Dihydrate AS A 2^ND Generation Macrolides).

Oral–
Adult: 500 mg once daily orally for 3 days or 500 mg once on day 1, then 250 mg once on days 2-5 for 4 days. For sexually transmitted diseases caused by Chlamydia trachomatis in adults, the dose is 1 gm given as a single dose or 500 mg once on day 1, followed by 250 mg once daily for next 2 days may also be given.

Children:

• 10 mg/kg body weight once daily for 3 days for child over 6 months
• 200 mg (1 teaspoonful) for 3 days if body weight is 15-25 kg
• 300 mg (1½ teaspoonfuls) for 3 days if body weight is 26-35 kg; 400 mg (2 teaspoonfuls) for 3 days if body weight is 36-45 kg.
• In typhoid fever, 500 mg (2½ teaspoonfuls) once daily for 7-10 days is given.

Azithromycin Injection (For IV Infusion only): The recommended dose of Azithromycin for injection for the treatment of adult patients with community-acquired pneumonia due to the indicated organisms is:

• 500 mg as a single daily dose by the intravenous route for at least two days. Intravenous therapy should be followed by Azithromycin by the oral route at a single, daily dose of 500 mg, administered as two 250-mg tablets to complete a 7 to 10-day course of therapy. The timing of the switch to oral therapy should be done at the discretion of the physician and in accordance with clinical response.
• The recommended dose of Azithromycin for the treatment of adult patients with pelvic inflammatory disease due to the indicated organisms is: 500 mg as a single daily dose by the intravenous route for one or two days. Intravenous therapy should be followed by Azithromycin by the oral route at a single, daily dose of 250 mg to complete a 7-day course of therapy. The timing of the switch to oral therapy should be done at the discretion of the physician and in accordance with clinical response. If anaerobic microorganisms are suspected of contributing to the infection, an antimicrobial agent with anaerobic activity should be administered in combination with Azithromycin.
• Safety and effectiveness of azithromycin for injection in children or adolescents under 16 years have not been established.

Side Effects of Tablet :-Zimax (AS A 𝐀𝐳𝐢𝐭𝐡𝐫𝐨𝐦𝐲𝐜𝐢𝐧 Dihydrate AS A 2^ND Generation Macrolides).

 

Zimax is well tolerated with a low incidence of side-effects. Most side-effects observed were mild to moderate in severity. The majority of side-effects were gastrointestinal in origin with nauseas, abdominal discomfort (pain/cramps), vomiting, flatulence, diarrhoea and loose stools being occasionally observed. Allergic reactions such as rash or photosensitivity have occurred and there have also been rare reports of serious hypersensitivity reactions. Reversible elevations in liver transaminases have been seen with a frequency similar to the comparative macrolides and penicillins used in clinical trials. Rarely, cases of cholestatic jaundice have been observed. Transient mild reductions in neutrofil counts have occasionally been observed in clinical trials, although a causal relationship to azithromycin has not been established. Hearing impairment: In investigational studies where higher doses were used for prolonged periods of time, reversible hearing impairment was seen in some patients.

Pregnancy & Lactation of Tablet :-Zimax (AS A 𝐀𝐳𝐢𝐭𝐡𝐫𝐨𝐦𝐲𝐜𝐢𝐧 Dihydrate AS A 2^ND Generation Macrolides).

 

Pregnancy Category of Azithromycin Dihydrate is B. Animal reproduction studies have demonstrated that Azithromycin has no evidence of harm to the fetus. There are no adequate and well controlled studies in pregnant women. Since animal reproduction studies are not always predictive of human response, Azithromycin should be used during pregnancy only if adequate alternatives are not available. It is not known whether Azithromycin is secreted in breast milk. So, caution should be exercised when Azithromycin is administered to nursing women.

Precautions & Warnings of Tablet :-Zimax (AS A 𝐀𝐳𝐢𝐭𝐡𝐫𝐨𝐦𝐲𝐜𝐢𝐧 Dihydrate AS A 2^ND Generation Macrolides).

 

As with erythromycin and other macrolides, rare serious allergic reactions, including angioneurotic oedema and anaphylaxis, has been reported. Some of these reactions with azithromycin have resulted in recurrent symptoms and required a long period of observation and treatment.

𝐀𝐳𝐢𝐭𝐡𝐫𝐨𝐦𝐲𝐜𝐢𝐧 (𝐙𝐢𝐦𝐚𝐱)Indications**

Upper & Lower RTI 500mg Daily ৫ দিন

Persistent uncontrolled অ্যাজমা 500 mg 3days Per Week-fr 48 সপ্তাহ

ACNE**500 mg 3days per Week–12 সপ্তাহ

Dental ইনফেকশন 500mg Once Daily (3-5) দিন

Typhoid fever 1 gm(two 500mg)Daily(7)দিন or

500 mg -OD-14 days*

Diarrhoea (No Cholera)500 mg Once daily (3-5) দিন

Diarrhoea & Cholera 1 gm Single ডোস

Genital Ulcer Disease (Chancroid) 1gm Single Dose(2 টা 500 mg)

Gonococcal Urethritis & Cervicitis 2 gm single Dose( 4 টা 500mg)…

Non-gonococcal Urethritis and Cervicitis 1 gm single dose(2 টা 500mg)..

General Quaries:-

1.diarrhoea te sir der deklam tab azyth 500 mg 2 ta 1st din dey,then 1 ta kore,

Answer is:-2 tab stat khbe

Jdi vlo hoye jay r drkr neii

Jdi vlo na hoy thn

Once daily again fr 4 days.

2.Jodi karo azithromycin hypersensitivity thake thle tar jnno drug of choice kon ta?

Answer is:-

Depend kore* Condition disease!

Raiyyan Tahsan Date:29-12-2024 Sunday Time:-4-31-35 Pm

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