Vonoprazan সবচেয়ে updated এবং শক্তিশালী Anti-ulcerent drug…যা বাংলাদেশে এই প্রথম!!এটি Potassium-Competitive Acid Blockers (P-CAB)…যা competitively H+ , K+ ATPase enzyme কে ইনহিবিট এর মাধ্যম কাজ করে…..যাকে Recent alternative of PPI বলা যায়…
বাজারে 10 mg& 20 mg how to use vonoprazan?
Tablet 1.Voniza (AS A Vonoprazan AS A Potassium competitive acid blocker.)
Vonifix
Vonozan
Vono
Vonocab এসব নামে পাওয়া যাচ্ছে
Vonoprazan এর Efficacy ,PPI থেকে বেশি **
Rapid Action & Duration of Action ও বেশি & more profound Acid suppression than PPii.
Better Acid control than PPIs
- Single Dose
Indications of Voniza drug:-
Voniza is indicated for:
- Gastric ulcer, duodenal ulcer, reflux esophagitis, prevention of recurrence of gastric or duodenal ulcer during low-dose aspirin administration, prevention of recurrence of gastric or duodenal ulcer during NSAID administration.
- Adjunct to Helicobacter pylori eradication in the following: Gastric ulcer, duodenal ulcer, gastric mucosa-associated lymphatic tissue (MALT) lymphoma, idiopathic thrombocytopenic purpura, the stomach after endoscopic resection of early-stage gastric cancer or Helicobacter pylori gastritis.
Indication
-GERD****
-Hyperacidity**
-Reflux Esophagitis & Related Disorders***
-Gastric Ulcer & Duodenal Ulcer
-Excellent healing fr ppi resistan EE
-Best choise হতে পারে H pylori induced Ulcer এর ট্রিটমেন্ট Triple Therpy তে
Side effects
-Long term ইউস এর ক্ষেত্রে same side effect As PPI
-Interference with nutrient absorption & Enteric infections এর রিস্ক বেড়ে যায় (Eg-Travelers diarrhoea)
-PCABS Gut microbiome এ Affect করতে পারে & potentially influencing infection risks.
-urticaria,Rash
- Precautions:-
Side Effects of Voniza Drug:-
Following side effects have been reported with the use of Voniza: Diarrhea, constipation, drug hypersensitivity (including anaphylactic shock), drug eruption, urticaria, hepatotoxicity, jaundice, rash, nausea, abdominal distension, gamma-glutamyl transferase increased, AST increased, Liver function test abnormal, ALT increased, ALP increased, LDH increased, y-GPT increased, edema and eosinophilia
-18 yrs এর নিচে recommend নয়
-পেশেন্ট With Hepatic & Renal impairment (Specially বয়স্কদের )
-avoid প্রেগন্যান্ট & lactating mothr!
-যে পেশেন্ট Atazanavir sulphate, nelfinavir or rilpivirine hydrochloride পাচ্ছে
N:B – নতুন Drug যত ভালো ই হোক সাবধানের সাথে use & Prescrive করাই ভালো .
General Quaries:-
1.Pregnency safe নয়।
১৮ বছরের নীচেও দেয়া যাবে না।
CKD তে দেয়া যাবে না।
Cardiac pt দের দেয়া যায় না।
Hepatic imparement থাকলে দেয়া যাবে না।
তাহলে safer কিভাবে হলো?
Answer is: dewa jabe but sob kisu exclude Kore dewa jabe.
2.Vonoprazan এর efficacy PPI থেকে বেশি এর source দেন। কোন হেড টু হেড স্টাডিতে পাওয়া গেছে।
Answer is: For reference
https://pubmed.ncbi.nlm.nih.gov/28657473
Raiyyan Tahsan Date:01-11-24 Friday at 11.00pm
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